Advancing Humanity: YZi Labs’ Vision for Web3, AI, and Biotech Innovation

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The future of innovation lies at the intersection of technology, human need, and purpose-driven leadership. At YZi Labs—formerly known as CZ’s $10 billion family office—the mission is clear: empower visionary founders building transformative solutions in Web3, artificial intelligence (AI), and biotechnology. With a growing portfolio, global incubation programs, and strategic hires, YZi Labs is accelerating the next wave of technological breakthroughs that aim to solve real-world challenges.

From decentralized finance to people-centered healthcare, from open-source crypto security to AI-powered scientific discovery, YZi Labs supports founders who are not just chasing trends but redefining industries. This article explores the latest developments across investments, team expansion, and incubation initiatives—all designed to foster long-term, impactful innovation.

Strategic Investments Powering the Future

YZi Labs has made a series of high-impact investments targeting foundational technologies in DeFi, crypto security, decentralized entertainment, and Bitcoin-powered finance.

Unlocking Bitcoin’s Economic Potential with Avalon Labs

Avalon Labs is building an on-chain capital market for Bitcoin, creating a scalable and transparent financial network that unlocks Bitcoin’s full economic utility. By enabling real-world financial applications directly on Bitcoin’s blockchain, Avalon Labs addresses one of the most pressing gaps in the ecosystem: usable, trustless financial infrastructure.

👉 Discover how next-gen Bitcoin finance is evolving beyond speculation.

YZi Labs’ investment underscores its commitment to projects that go beyond incremental improvements—focusing instead on systemic transformation. Avalon Labs represents a bold step toward making Bitcoin not just a store of value, but a functional engine for decentralized finance.

Strengthening Multichain DeFi with Blueprint Finance

Blueprint Finance is advancing multichain liquidity through its ecosystem, which includes Concrete Protocol and Glow Finance. These protocols are developing institutional-grade DeFi tools such as portable margin accounts, automated yield vaults, and enhanced staking markets—features critical for broader adoption by professional investors.

With YZi Labs’ backing, Blueprint Finance is poised to accelerate innovation in cross-chain interoperability and risk management, two of the most complex challenges in modern decentralized finance.

Democratizing Fan Engagement via MEET48

MEET48, a decentralized social (DeSoc) entertainment platform incubated under BNB’s MVB Accelerator, is reimagining fan participation in the idol economy. Through token-driven engagement models, fans can now influence content creation, attend virtual performances, play idol management games, and participate in real-world events—all while building ownership in the ecosystem.

This investment reflects YZi Labs’ belief that Web3 can humanize digital experiences, turning passive audiences into active stakeholders.

Enhancing Global Crypto Security with OneKey

OneKey’s open-source hardware wallets offer secure self-custody solutions for both retail and institutional users. As cyber threats grow more sophisticated, the need for affordable, transparent, and user-friendly security tools has never been greater.

YZi Labs’ investment reinforces its focus on gateway technologies—tools that make Web3 safer and more accessible for newcomers. OneKey’s global reach across Asia, Europe, Australia, and South America makes it a key player in mainstream crypto adoption.

Leadership Expansion: Deepening Expertise in AI and Biotech

To guide these ambitious initiatives, YZi Labs has strengthened its leadership team with world-class talent from top academic and tech institutions.

Jane He Joins as General Partner to Lead Biotech Vision

Jane He brings decades of experience in life sciences investing to her role as General Partner. Her appointment marks a strategic shift toward people-centered biotech and healthcare innovation—a theme deeply personal to her.

“I’ll never forget the first time I sat down with CZ. We began talking about science, but quickly turned to the patients who fall through the cracks—the families waiting for answers,” recalls Jane. “There was a sense of urgency: things could be better.”

Under her leadership, YZi Labs will prioritize innovations that bridge scientific advancement with human impact—supporting founders developing therapies, diagnostics, and health platforms that serve underserved populations.

Jing Xiong Leads AI and Emerging Tech Investments

Jing Xiong, formerly with Google and Stanford University, now serves as Investment Director at YZi Labs. Her background in computer vision, neuroscience, and AI product development—spanning projects like Google Lens and Gemini—positions her uniquely to identify breakthrough opportunities at the convergence of AI, Web3, and biotech.

“I thought I knew what to expect—backing bold AI founders,” says Jing. “But nothing prepared me for what I found behind Giggle Academy.”

Her journey reflects a broader realization: the most impactful technologies are not just technically advanced—they are deeply human.

EASY Residency: A Global Incubation Program for Visionary Founders

Recognizing that funding alone isn’t enough, YZi Labs launched EASY Residency, a 10-week in-person incubation program for early-stage founders in Web3, AI, and biotech.

Designed for the top 1% of innovators, the program kicks off in New York City and offers:

Cathy Dou has been appointed as Incubation Operations Lead to oversee the rollout. With a proven track record in founder development, she ensures participants receive holistic support—not just capital, but clarity.

“The founder’s journey is never EASY,” reads the program’s tagline. “Too many bold ideas fade away—not from lack of potential, but because of constant distractions.”

YZi Labs believes that removing friction allows genius to flourish.

Driving Innovation Through Global Hackathons

To spark grassroots innovation, YZi Labs partnered with AGI House and DoraHacks to launch dual-format hackathons:

These events invite developers, researchers, and entrepreneurs to build next-generation fintech solutions powered by AI and blockchain. Alongside technical challenges, YZi Labs hosted a BUIDLer Breakfast networking event to connect emerging talent with seasoned investors and builders.

Such initiatives reflect a core philosophy: innovation thrives when diverse minds collaborate across borders and disciplines.

Frequently Asked Questions (FAQ)

What is YZi Labs?

YZi Labs is a global investment and incubation firm focused on transformative technologies in Web3, artificial intelligence, and biotechnology. It supports early-stage founders through funding, mentorship, and hands-on programs like EASY Residency.

Is YZi Labs only focused on blockchain?

No. While it began with strong roots in Web3 and crypto infrastructure, YZi Labs has expanded into AI and biotech—investing in projects that solve real human problems using cutting-edge science and technology.

How can I apply to EASY Residency?

Applications for EASY Residency are open to early-stage founders in Web3, AI, and biotech. Visit the official YZi Labs website for application details, deadlines, and program requirements.

👉 Explore opportunities for innovators shaping the future.

Who are some of YZi Labs’ portfolio companies?

Notable investments include OneKey (crypto security), Avalon Labs (Bitcoin finance), Blueprint Finance (multichain DeFi), MEET48 (decentralized entertainment), and DoraHacks (developer platform).

Does YZi Labs invest outside the U.S.?

Yes. YZi Labs operates globally, with investments and incubation programs spanning Asia, Europe, South America, and beyond. Its mission is to back exceptional founders regardless of geography.

What makes YZi Labs different from other venture firms?

YZi Labs combines deep technical expertise with a long-term vision for human-centered innovation. Rather than chasing short-term returns, it focuses on foundational technologies that can drive lasting societal impact.

Core Keywords

YZi Labs continues to build an ecosystem where science meets purpose, where code empowers communities, and where visionaries are given the tools—and the space—to change the world.